Professor Gareth Inman is Director of Research Strategy at the CRUK Scotland Institute, Research Theme lead for the CRUK Scotland Centre and Director of Research and Professor of Cell Signalling in the School of Cancer Sciences in the University of Glasgow and is helping to shape the cancer research strategy in Scotland. Following his PhD studies and postdoctoral work in New York and London, Gareth established his own laboratory in Glasgow in 2003 to investigate the role of transforming growth factors in cancer development and progression. Our studies have revealed that these factors are intimately involved in cutaneous squamous cell carcinoma (cSCC) development in both the general population and in Epidermolysis Bullosa patients and this has lead us to take a leading role in deciphering the molecular landscape of SCC disease progression using a variety of next generation sequencing techniques. We are now investigating the biology of cSCC and Head and Neck SCC initiation, metastasis and response to treatment and are developing patient relevant pre-clinical models to identify potential therapeutic vulnerabilities and biomarkers to guide their exploitation for patient benefit.